MG53 E3 Ligase-dead Mutant Protects Diabetic Hearts from Acute Ischemic/Reperfusion Injury and Ameliorates Diet-induced Cardiometabolic Damage

MG53 E3 Ligase-dead Mutant Protects Diabetic Hearts from Acute Ischemic/Reperfusion Injury and Ameliorates Diet-induced Cardiometabolic Damage james freeman diabetes freedom Cardiometabolic diseases, including diabetes and its cardiovascular complications, are the global leading cause of death, highlighting a major unmet medical Read more

Savvy Updates, 11/8/21: New Ultra-Rapid Insulin BioChaperone, Non-Invasive CGM Really?, Capsinoids & BG Control, GLP-1 & More Benefits, Gastroparesis Benefits from Closed Loops Systems

Savvy Updates, 11/8/21: New Ultra-Rapid Insulin BioChaperone, Non-Invasive CGM Really?, Capsinoids & BG Control, GLP-1 & More Benefits, Gastroparesis Benefits from Closed Loops Systems type 2 diabetes can be reversed Adocia’s Partner Tonghua Dongbao Receives Clearance to Start Ultra-Rapid Insulin Read more

Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Cross-Over LIRALUNG Study.

Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Cross-Over LIRALUNG Study. james freeman diabetes freedom Aims/hypothesis: To evaluate the effect of liraglutide, a glucagon-like peptide 1 receptor agonist, on pulmonary function and serum Read more

Increased Energy Expenditure and Protection from Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9

Increased Energy Expenditure and Protection from Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9 james freeman diabetes freedom Cyclic nucleotides, cAMP and cGMP, are important second messengers for the regulation of adaptive thermogenesis. Their levels are controlled not only Read more

Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms

Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms james freeman diabetes freedom Recognition of beta-cell antigens by autoreactive T cells is a critical step in the initiation of autoimmune Type1 diabetes (T1D). A complete protection from diabetes Read more

Lipid Droplets Protect Human {beta} Cells from Lipotoxic-Induced Stress and Cell Identity Changes

Lipid Droplets Protect Human {beta} Cells from Lipotoxic-Induced Stress and Cell Identity Changes james freeman diabetes freedom Free fatty acids (FFAs) are often stored in lipid droplet (LD) depots for eventual metabolic and/or synthetic use in many cell types, such Read more

Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages

Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages james freeman diabetes freedom Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on Read more

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota That Protects From Metabolic Diseases

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota That Protects From Metabolic Diseases james freeman diabetes freedom Excess chronic contact between microbial motifs and intestinal immune cells is known to trigger a low-grade inflammation involved in many pathologies such as Read more

TM4SF5 Knockout Protects Mice From Diet-Induced Obesity Partly by Regulating Autophagy in Adipose Tissue

TM4SF5 Knockout Protects Mice From Diet-Induced Obesity Partly by Regulating Autophagy in Adipose Tissue james freeman diabetes freedom Transmembrane 4 L six family member 5 (TM4SF5) functions as a sensor for lysosomal arginine levels and activates the mammalian target of Read more

From Pancreatic {beta}-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

From Pancreatic {beta}-Cell Gene Networks to Novel Therapies for Type 1 Diabetes james freeman diabetes freedom Completion of the Human Genome Project enabled a novel systems- and network-level understanding of biology, but this remains to be applied for understanding the Read more

Multicomponent Plasmid Protects Mice From Spontaneous Autoimmune Diabetes

Multicomponent Plasmid Protects Mice From Spontaneous Autoimmune Diabetes james freeman diabetes freedom Type 1 diabetes is an autoimmune disease in which insulin-secreting β-cells are destroyed, leading to a life-long dependency on exogenous insulin. There are no approved disease-modifying therapies available, Read more

Mostar Bridge Jump: How To Jump From Stari Most Bridge!

Mostar Bridge Jump: How To Jump From Stari Most Bridge! george reilly diabetes freedom https://uploads-ssl.webflow.com/576fd5a8f192527e50a4b95c/5b42088c169a33cd749cf057_Mostar%20Bridge%20Jump%202018.jpg When driving through Bosnia Herzegovina, one of the best things you can do is the Mostar Bridge jump! It’s only 23 metres high, think you Read more

From Mason Jars to Fridge Hacks – Ways We Store Our Food

From Mason Jars to Fridge Hacks – Ways We Store Our Food diet for type 2 diabetes reversal https://1.bp.blogspot.com/-_bsa-s0NB6k/YRMAUG5uu0I/AAAAAAAAa30/x_bPlq5byVUWlIU1ZZ7arMiJGZOWe_TxgCLcBGAsYHQ/s72-w640-h360-c/fridgehacks.jpg Tess Patrick at Food Matters site writes: “Any foodie will tell you that the key to a kitchen is a handful Read more

Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages

Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages james freeman diabetes freedom Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on Read more

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases james freeman diabetes freedom Excess chronic contact between microbial motifs and intestinal immune cells is known to trigger a low-grade inflammation involved in many pathologies such as Read more

TM4SF5 knockout protects mice from diet-induced obesity partly by regulating autophagy in adipose tissue

TM4SF5 knockout protects mice from diet-induced obesity partly by regulating autophagy in adipose tissue james freeman diabetes freedom Transmembrane 4 L six family member 5 (TM4SF5) functions as a sensor for lysosomal arginine levels and activates the mammalian target of Read more

Savvy Concerns, 8/4/21: Remission or Cure with The Sugar Science, Plant-based Cheese, Abbott $160M in Fines for Kickbacks, 4% DNA Difference from Chimps

Savvy Concerns, 8/4/21: Remission or Cure with The Sugar Science, Plant-based Cheese, Abbott 0M in Fines for Kickbacks, 4% DNA Difference from Chimps type 2 diabetes can be reversed Join The Sugar Science as they present the State of The Read more

Chronic Antidiabetic Actions of Leptin: Evidence from Parabiosis Studies for a CNS-Derived Circulating Antidiabetic Factor

Chronic Antidiabetic Actions of Leptin: Evidence from Parabiosis Studies for a CNS-Derived Circulating Antidiabetic Factor james freeman diabetes freedom We used parabiosis to determine whether the central nervous system (CNS)-mediated antidiabetic effects of leptin are mediated by release of a Read more

Metformin Perturbs Pancreatic Differentiation From Human Embryonic Stem Cells

Metformin Perturbs Pancreatic Differentiation From Human Embryonic Stem Cells james freeman diabetes freedom Metformin is becoming a popular treatment before and during pregnancy, but current literature on in utero exposure to metformin lacks long-term clinical trials and mechanistic studies. Current Read more

Differential DNA Methylation and Expression of MicroRNAs in Adipose Tissue from Twin Pairs Discordant for Type 2 Diabetes

Differential DNA Methylation and Expression of MicroRNAs in Adipose Tissue from Twin Pairs Discordant for Type 2 Diabetes james freeman diabetes freedom The prevalence of type 2 diabetes (T2D) is increasing worldwide but current treatments have limitations. MicroRNAs (miRNAs) may Read more