How beneficial are foot-ankle flexibility and resistance exercises for preventing foot diabetic ulcer recurrence?

How beneficial are foot-ankle flexibility and resistance exercises for preventing foot diabetic ulcer recurrence? dr freeman type 2 diabetes cure In a nutshell This study assessed the effect of foot-ankle flexibility and resistance exercises in the prevention and recurrence of Read more

How effective is a new macrophage-regulating drug for wound healing in patients with diabetic foot ulcers?

How effective is a new macrophage-regulating drug for wound healing in patients with diabetic foot ulcers? dr freeman type 2 diabetes cure In a nutshell This study compared the therapeutic benefit of topically applied ON101 (Fespixon) cream to an absorbent dressing Read more

Possible Involvement of Adipose Tissue in Older and Obese Diabetic Patients with Coronavirus SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

Possible Involvement of Adipose Tissue in Older and Obese Diabetic Patients with Coronavirus SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19 james freeman diabetes freedom Aging, obesity and diabetes are major risk factors for the severe Read more

Savvy Updates, 9/27/21: Euglycemic Diabetic Ketoacidosis, Surge in Pediatric T1D, D & Tuberculosis, Insulin Resistance, Wireless Charging IKEA gadget

Savvy Updates, 9/27/21: Euglycemic Diabetic Ketoacidosis, Surge in Pediatric T1D, D & Tuberculosis, Insulin Resistance, Wireless Charging IKEA gadget type 2 diabetes can be reversed Diabetic Ketoacidosis (DKA) Without High Blood Sugar? Yikes! was written by Moira McCarthy for DiabetesMine.com, Read more

Syntaxin 4 enrichment in {beta}-cells prevents conversion to autoimmune diabetes in non-obese diabetic (NOD) mice

Syntaxin 4 enrichment in {beta}-cells prevents conversion to autoimmune diabetes in non-obese diabetic (NOD) mice james freeman diabetes freedom Syntaxin 4 (STX4), a plasma membrane-localized SNARE protein, regulates human islet β-cell insulin secretion and preservation of β-cell mass. We found Read more

Activation of HIF1{alpha} Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart

Activation of HIF1{alpha} Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart james freeman diabetes freedom Type 2 diabetes (T2D) impairs Hypoxia-Inducible Factor (HIF)1α activation, a master transcription factor that drives cellular adaptation to hypoxia. Reduced activation Read more

Effect of Systemic Hypertension on Peripapillary RNFL Thickness in Diabetic Patients Without Diabetic Retinopathy

Effect of Systemic Hypertension on Peripapillary RNFL Thickness in Diabetic Patients Without Diabetic Retinopathy james freeman diabetes freedom Type 2 diabetes (T2DM) and hypertension (HTN) are both relatively common systemic diseases and cause damage to the retina, such as inner Read more

Do eye injections reduce the risk of blindness in patients with severe diabetic eye disease?

Do eye injections reduce the risk of blindness in patients with severe diabetic eye disease? dr freeman type 2 diabetes cure In a nutshell This study looked at the use of aflibercept (Eylea) eye injections for the treatment of severe nonproliferative diabetic Read more

Mineralocorticoid Receptor Pathway and its Antagonism in a Model of Diabetic Retinopathy

Mineralocorticoid Receptor Pathway and its Antagonism in a Model of Diabetic Retinopathy james freeman diabetes freedom Diabetic retinopathy remains a major cause of vision loss worldwide. Mineralocorticoid receptor (MR) pathway activation contributes to diabetic nephropathy but its role in retinopathy Read more

Vaccination Against Receptor for Advanced Glycation End Products Attenuates the Progression of Diabetic Kidney Disease

Vaccination Against Receptor for Advanced Glycation End Products Attenuates the Progression of Diabetic Kidney Disease james freeman diabetes freedom Effective treatment of diabetic kidney disease (DKD) remains a large unmet medical need. Within the disease’s complicated pathogenic mechanism, activation of Read more

Toll-Like Receptor 2 Deficiency Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1

Toll-Like Receptor 2 Deficiency Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1 james freeman diabetes freedom We have previously demonstrated a novel role of bone morphogenic protein 4 (BMP4) in inducing NOX1-dependent endothelial nitric oxide Read more

Are vitamin B12 injections more effective than vitamin B12 tablets for treating diabetic nerve damage?

Are vitamin B12 injections more effective than vitamin B12 tablets for treating diabetic nerve damage? dr freeman type 2 diabetes cure In a nutshell This study compared mecobalamin (vitamin B12) injections with mecobalamin tablets for the treatment of diabetic peripheral neuropathy Read more

Overexpression of GPR40 in Pancreatic {beta}-Cells Augments Glucose Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

Overexpression of GPR40 in Pancreatic {beta}-Cells Augments Glucose Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice james freeman diabetes freedom Objective: GPR40 is a G protein-coupled receptor regulating free fatty acid-induced insulin secretion. We have generated Read more

VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy

VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy james freeman diabetes freedom Foot process effacement is an important feature of early diabetic nephropathy (DN) which is closely related to the development of Read more

The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through AMPK/PPAR{alpha}/CPT1b pathway

The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through AMPK/PPAR{alpha}/CPT1b pathway james freeman diabetes freedom Inflammation and abnormal metabolism play important roles in the pathogenesis of diabetic nephropathy (DN). Annexin A1 (ANXA1) contributes to inflammation Read more

Toll-like Receptor 2 (TLR2) Deficiency Abrogates Diabetic and Obese Phenotypes while Restoring Endothelial Function via Inhibition of NOX1

Toll-like Receptor 2 (TLR2) Deficiency Abrogates Diabetic and Obese Phenotypes while Restoring Endothelial Function via Inhibition of NOX1 james freeman diabetes freedom We have previously demonstrated a novel role of bone morphogenic protein-4 (BMP4) in inducing NOX1-dependent eNOS uncoupling, endothelial Read more

Vaccination against receptor for advanced glycation end products attenuates the progression of diabetic kidney disease

Vaccination against receptor for advanced glycation end products attenuates the progression of diabetic kidney disease james freeman diabetes freedom Effective treatment of diabetic kidney disease (DKD) remains a large unmet medical need. Within the disease’s complicated pathogenic mechanism, activation of Read more

Perirenal fat thickness is significantly associated with the risk for development of chronic kidney disease in diabetic patients

Perirenal fat thickness is significantly associated with the risk for development of chronic kidney disease in diabetic patients james freeman diabetes freedom Perirenal fat is adjacent to kidneys and active in metabolism and adipokine secretion. We aimed to investigate whether Read more

Profile of podocyte translatome during development of type 2 and type 1 diabetic nephropathy using podocyte-specific TRAP mRNA RNA-seq

Profile of podocyte translatome during development of type 2 and type 1 diabetic nephropathy using podocyte-specific TRAP mRNA RNA-seq james freeman diabetes freedom Podocyte injury is important in development of diabetic nephropathy (DN). Although several studies have reported single cell-based Read more

Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy

Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy james freeman diabetes freedom The current understanding of the molecular pathogenesis of diabetic retinopathy does not provide a mechanistic link between early molecular changes and the subsequent progression of Read more

Metabolomics Profiling of Patients With A-{beta}+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis

Metabolomics Profiling of Patients With A-{beta}+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis james freeman diabetes freedom When stable and near-normoglycemic, patients with “A–β+” ketosis-prone diabetes (KPD) manifest accelerated leucine catabolism and blunted ketone oxidation, which may underlie their proclivity to develop Read more