Hepatic P38 Activation Modulates Systemic Metabolism Through Fgf21-Mediated Interorgan Communication

Hepatic P38 Activation Modulates Systemic Metabolism Through Fgf21-Mediated Interorgan Communication james freeman diabetes freedom The mechanisms underlying the pathogenesis of steatosis and insulin resistance in nonalcoholic fatty liver disease remain elusive. Increased phosphorylation of hepatic p38 has long been noticed Read more

Activation of HIF1{alpha} Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart

Activation of HIF1{alpha} Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart james freeman diabetes freedom Type 2 diabetes (T2D) impairs Hypoxia-Inducible Factor (HIF)1α activation, a master transcription factor that drives cellular adaptation to hypoxia. Reduced activation Read more